Monash University
Final Thesis 18-May 2022.pdf (6.16 MB)

Creatine metabolism in human pregnancy and the potential for oral creatine supplementation in pregnancy

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posted on 2023-03-08, 01:26 authored by Deborah Louise De Guingand

Globally, 4 million neonatal deaths occur annually. Many occur as a result of an acute low oxygen event to the fetus during labour or birth (intrapartum asphyxia). Currently, no oral therapy can minimise the impact of these unpredictable events. Maternal creatine supplementation during pregnancy could support ongoing cellular energy production and safeguard fetal organs from harm due to low oxygen. Although pre-clinical laboratory science is strong, further questions need to be answered, before progressing to human clinical trials. This thesis details the identified gaps in our knowledge and the translational research work undertaken to inform future pregnancy clinical trials.


Principal supervisor

Stacey Joan Ellery

Additional supervisor 1

Kirsten Palmer

Year of Award


Department, School or Centre

Obstetrics and Gynaecology

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses