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CppA: A putative major fimbrial protein and novel virulence factor for clostridial myonecrosis

thesis
posted on 09.02.2021, 06:57 authored by DANIELLE FRANCES D'SOUZA
Clostridium perfringens is a bacterium that causes a ‘flesh-eating disease’ known as clostridial myonecrosis, primarily by producing potent toxins. This thesis examines a novel surface protein, CppA, which was shown to be a novel non-toxin disease determinant. CppA was also shown to form fimbriae-like appendages on the cell and potentially contributes to disease by mediating colonisation of host tissues. Therefore, the research described in this thesis has contributed to the knowledge of non-toxin disease factors for clostridial myonecrosis.

History

Principal supervisor

Julian Rood

Additional supervisor 1

Xiaoyan Han

Year of Award

2021

Department, School or Centre

Microbiology

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences