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CppA: A putative major fimbrial protein and novel virulence factor for clostridial myonecrosis

posted on 2021-02-09, 06:57 authored by DANIELLE FRANCES D'SOUZA
Clostridium perfringens is a bacterium that causes a ‘flesh-eating disease’ known as clostridial myonecrosis, primarily by producing potent toxins. This thesis examines a novel surface protein, CppA, which was shown to be a novel non-toxin disease determinant. CppA was also shown to form fimbriae-like appendages on the cell and potentially contributes to disease by mediating colonisation of host tissues. Therefore, the research described in this thesis has contributed to the knowledge of non-toxin disease factors for clostridial myonecrosis.


Principal supervisor

Julian Rood

Additional supervisor 1

Xiaoyan Han

Year of Award


Department, School or Centre



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences