Monash University
Amended Final Thesis_Signed_Clean.pdf (2.35 MB)
Download file

Cortical Morphometry and Neural Dysfunction in Huntington's Disease

Download (2.35 MB)
posted on 2022-08-31, 05:08 authored by BRENDAN KER HUI TAN
This thesis is the first to investigate how cortical morphometry (shape) and white matter tractography (connectivity) of specific brain regions change in Huntington’s disease. The aim of this thesis was to better understand the nature, time course and relationship of these changes and their impact on the clinical symptoms observed in the disease. To achieve this aim, longitudinal neuroimaging and clinical data from the Melbourne-based IMAGE-HD study was used. The findings of this thesis provide novel insights that further enhance our knowledge of the progression of disease, specifically highlighting pronounced morphometry abnormalities, and reduced integrity of tracts occurring at different stages of disease.


Principal supervisor

Nellie Georgiou-karistianis

Additional supervisor 1

Rosita Shishegar

Additional supervisor 2

Alexander Fornito

Additional supervisor 3

Govinda Poudel

Year of Award


Department, School or Centre

Psychological Sciences

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences