Cortical Morphometry and Neural Dysfunction in Huntington's Disease

This thesis is the first to investigate how cortical morphometry (shape) and white matter tractography (connectivity) of specific brain regions change in Huntington’s disease. The aim of this thesis was to better understand the nature, time course and relationship of these changes and their impact on the clinical symptoms observed in the disease. To achieve this aim, longitudinal neuroimaging and clinical data from the Melbourne-based IMAGE-HD study was used. The findings of this thesis provide novel insights that further enhance our knowledge of the progression of disease, specifically highlighting pronounced morphometry abnormalities, and reduced integrity of tracts occurring at different stages of disease.