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Concise Access to Heteracenes and Cycloptenanoids through Alkyne Activation: sp to sp2 to sp3 Conversions

thesis
posted on 10.07.2020 by YU LEUK LAW
Alkynes are considered as one of the simplest and most accessible building blocks in organic chemistry. Manipulation with these modular building blocks enables concise and stereoselective synthesis into sp2- and sp3-rich compounds, which provide new opportunities in material and medical science. Notwithstanding the effort and interest in sp2- and sp3- rich compounds syntheses, progress around these area of research has been hampered by stepwise syntheses of such complicated structures, which effectively increases the cost of mass-production. This thesis presents new synthetic approaches towards both sp2- and sp3-rich molecules via heteroatomic electrophilic activation of alkynes and torquoselective Nazarov cyclization, respectively.

History

Campus location

Australia

Principal supervisor

Bernard Flynn

Additional supervisor 1

Dr. Luigi Aurelio

Year of Award

2020

Department, School or Centre

Medicinal Chemistry

Additional Institution or Organisation

Monash Institution of Pharmaceutical Science

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Exports

Exports