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Concise Access to Heteracenes and Cycloptenanoids through Alkyne Activation: sp to sp2 to sp3 Conversions
thesisposted on 10.07.2020 by YU LEUK LAW
In order to distinguish essays and pre-prints from academic theses, we have a separate category. These are often much longer text based documents than a paper.
Alkynes are considered as one of the simplest and most accessible building blocks in organic chemistry. Manipulation with these modular building blocks enables concise and stereoselective synthesis into sp2- and sp3-rich compounds, which provide new opportunities in material and medical science. Notwithstanding the effort and interest in sp2- and sp3- rich compounds syntheses, progress around these area of research has been hampered by stepwise syntheses of such complicated structures, which effectively increases the cost of mass-production. This thesis presents new synthetic approaches towards both sp2- and sp3-rich molecules via heteroatomic electrophilic activation of alkynes and torquoselective Nazarov cyclization, respectively.