Monash University
Thesis-Final.pdf (80.61 MB)

Commonalities in clonal selection during normal tissue and cancer development

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posted on 2023-03-30, 01:26 authored by ABBAS SALAVATY HOSEIN ABADI
Clonal selection and drift (i.e. proliferation and dominance of some cell clones and extinction of others, respectively) are critical phenomena during development. To evaluate the commonalities of this phenomena during normal tissue and cancer development we recruited computational techniques to analyze both normal and cancer tissue data. Also, several models, algorithms, and tools were developed to solve different problems we faced throughout the project. The comparative analyses revealed that while there are major differences in the drivers of selection in normal and cancer tissues, some key genes are common across different tissues and even between normal and cancerous ones.


Principal supervisor

Peter Currie

Additional supervisor 1

Mirana Ramialison

Year of Award


Department, School or Centre

Australian Regenerative Medicine Institute (ARMI)

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences