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Cognition across the schizotypy-schizophrenia continuum and the role of the glutamatergic system

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posted on 20.09.2019, 05:15 by ELIZABETH HUI XIN THOMAS
Cognitive impairment is a core symptom frequently reported in schizophrenia and believed to be influenced by glutamatergic genes. It is believed that the symptoms of schizophrenia such as cognition lie on a continuum, known as schizotypy. This theory of schizotypy suggests that the characteristics of schizophrenia can be observed in the general population but at a sub-clinical level. This thesis investigates cognition across the schizotypy-schizophrenia continuum and demonstrates the role of the glutamatergic system. It is hoped that this research will reduce stigma surrounding mental illness and contribute to the development of targeted treatment for cognitive symptoms.


Principal supervisor

Caroline Gurvich

Additional supervisor 1

Susan Rossell

Additional supervisor 2

Kiymet Bozaoglu

Year of Award


Department, School or Centre

Central Clinical School

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences