Monash University
Shen Thesis Final Version - Amendments.pdf (4.34 MB)

Clinical and Economic Evaluation of Anticoagulant Interventions for Stroke Prevention in Patients with Atrial Fibrillation

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posted on 2020-03-18, 23:24 authored by Siok Shen Ng
Many new anticoagulant interventions have emerged for stroke prevention in atrial fibrillation such as novel oral anticoagulants (NOACs) and warfarin care bundles. To date, the overall efficacy and cost-effectiveness of warfarin care bundles in comparison with NOACs is still unknown, especially in the healthcare context of low- and middle-income countries. Therefore, this thesis aimed to explore the clinical and economic outcomes of these interventions in patients with atrial fibrillation, in such healthcare setting. This thesis demonstrated the value of clinical evidence obtained systematically and how economic evaluation may facilitate healthcare decision-making on the choices of anticoagulants, based on scarce resources allocation.


Principal supervisor

Nathorn Chaiyakunapruk

Additional supervisor 1

Nai Ming Lai

Additional supervisor 2

Nowrozy Kamar Jahan

Year of Award


Department, School or Centre

Jeffrey Cheah School of Medicine and Health Sciences (Monash University Malaysia)

Additional Institution or Organisation

Jeffrey Cheah School of Medicine and Health Sciences

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences