Embargoed and Restricted Access
Reason: Under embargo until 9 May 2025. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
Chrysin and Lentinan Co-Treatment Induces Apoptosis and Ferroptosis by Regulating Metabolic, Apoptotic and Immune-System related Proteins in Human Glioblastoma
thesis
posted on 2024-05-09, 05:18 authored by AYESHA ATIQThe standard therapy for glioblastoma lead to fatalities, underscoring the need for more effective treatments. Natural products such as chrysin and lentinan, hold promise as anti-cancer agents. Their combined potential that may offer as a better anti-cancer agents remains unexplored. Current study evaluated the anti-cancer effects of chrysin and lentinan combination in A-172 and T98G GBM cells. The findings describe the synergistic cell death effects of chrysin and lentinan through activation of apoptosis which further leads to ferroptosis induction in GBM cells. Proteomics analysis reveals that the enhancement of metabolism and immune system contributes to apoptosis and ferroptosis-mediated cell death
