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Chronic Outcomes after Traumatic Brain Injury: Investigating Cognitive Decline, Brain Age and Risk of Alzheimer’s Disease

thesis
posted on 09.04.2022, 01:11 by AMELIA HICKS
This thesis examined the chronic long-term period (≥ 10 years) following a single moderate to severe traumatic brain injury (TBI). We found that TBI results in a persistent but stable change in cognitive function. Individuals with TBI had biologically ‘older’ brains, which was estimated from MR imaging of grey and white matter. This change to ‘brain age’ was also stable over time and we found no evidence of accelerated brain ageing. Finally, we found no evidence that the pathological hallmarks of Alzheimer’s disease, amyloid-β and tau pathology, persist or accumulate in the chronic period after TBI.

History

Principal supervisor

Jennie Louise Ponsford

Additional supervisor 1

Dr Gershon Spitz

Year of Award

2022

Department, School or Centre

Psychological Sciences

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences