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Chemical biology tools for the characterisation and exploitation of antibiotic biosynthetic pathways

thesis
posted on 2023-09-07, 05:29 authored by YEE TING CANDACE HO
The development of new classes of antibiotics for clinical use is of great importance due to the ever-increasing threat of antimicrobial resistance. This includes peptide antibiotics, which are enzymatically produced by non-ribosomal peptide synthases. Biotechnological approaches to diversify the products of this biosynthetic pathway have great potential for future antibiotic development. In my PhD, chemical biology tools were developed to provide insight into nonribosomal peptide (NRP) biosynthesis, with the aim of enabling future antibiotic diversification. Ultimately, these results represent major progress toward the goal of engineering NRP biosynthesis to produce potent, novel antimicrobial peptides for clinical use.

History

Principal supervisor

Max Cryle

Additional supervisor 1

Manuela Tosin

Additional supervisor 2

Julien Tailhades

Additional supervisor 3

Thierry Izoré

Year of Award

2023

Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Biochemistry and Molecular Biology

Campus location

Australia

Course

Doctor of Philosophy (Monash - Warwick)

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences