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Characterization of the mechanism of z-FA-FMK anti-proliferative effects and cysts induction in Toxoplasma gondii

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thesis
posted on 15.04.2020 by ENG HWA YEO
This thesis studies the effect of a protease inhibitor known as z-FA-FMK on the growth of the intracellular parasite Toxoplasma gondii. During infection, the parasite can change from active infectious form to dormant form and eventually form cyst. Dormant parasites in cysts are difficult to be eradicated by currently available drug treatment. In this thesis, we found that z-FA-FMK inhibits Toxoplasma gondii growth and induce them to form cyst through inducing nutrient starvation.

History

Campus location

Malaysia

Principal supervisor

Chow Sek Chuen

Year of Award

2020

Department, School or Centre

School of Sciences (Monash University Malaysia)

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Exports

Exports