Characterization of The Functional Role of PEAK1 and PEAK3 Pseudokinases

The three pseudokinases PEAK1, PEAK2 and the recently identified PEAK3 constitute the PEAK family. Both PEAK1 and PEAK2 function as scaffolds to regulate cell proliferation, migration and invasion. PEAK3 is a novel pseudokinase, whose signalling pathways and function remain poorly characterized. In this thesis, the role of PEAK1 in mammary gland development and PEAK3 signalling mechanisms and function were characterized.