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Reason: Under embargo until 15 February 2023. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
Characterising the molecules involved in axonal repair
thesis
posted on 2022-02-21, 23:17 authored by TARIKA VIJAYARAGHAVANAxonal fusion is a neuronal repair mechanism that results in the reconnection of severed axon fragments and the restoration of cytoplasmic continuity and neuronal function. While synaptic vesicle recycling has been linked to axonal regeneration, its role in axonal fusion remains largely unknown. Dynamin proteins are large GTPases that hydrolyse lipid-binding membranes to carry out clathrin-mediated synaptic vesicle recycling. Using the model organism Caenorhabditis elegans, we report that DYN-1/Dynamin-1 is a novel regulator of axonal fusion and lies upstream to the fusogen EFF-1 to repair the peripheral neuron.
