L92 Krupesh PATEL_Complete Thesis-2018-11-19_Redacted.pdf (23.39 MB)

Characterising and Treating a Refined Model of Allergic Airways Disease that mimics the key features of Human Asthma

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thesis
posted on 13.03.2019, 22:15 by KRUPESH PATEL
This thesis established a refined model of chronic allergic airways disease (AAD) that incorporated epithelial damage as a component of its pathology, and hence better mimicked the progression of human asthma (Aim 1). Using this refined model it then evaluated the therapeutic potential of various individual (relaxin (RLX), trefoil factor (TFF)2, dexamethasone (DEX), amnion epithelial stem cell-derived exosomes (AEC-EXO)) and combination (RLX+TFF2, RLX+TFF2+DEX, RLX+AEC-EXO, RLX+AEC) treatment strategies (Aim 2 and Aim 3) for treating the three central components of asthma: airway inflammation, airway remodelling, and airway hyperresponsiveness.

History

Principal supervisor

Chrishan Samuel

Additional supervisor 1

Simon Royce

Year of Award

2018

Department, School or Centre

Pharmacology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

Exports

Categories

Exports