Monash University

Embargoed and Restricted Access

Reason: Under embargo until November 2023. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Characterising Plasminogen and Receptor Interactions in Macrophage Function

posted on 2020-11-03, 00:18 authored by BLAKE ANTHONY MAZZITELLI
Macrophages are crucial cells of the immune system, being vital players in the response against infection and injury. Macrophages rely on the protein Plasminogen and its receptors (known as Plasminogen Receptors) for a variety of important functions. In this thesis, we sought to understand the specific ways that Plasminogen mediates macrophage functions. We have investigated and gained new insights into the molecular interaction between Plasminogen and its receptors. Beyond these receptors, we have also begun to uncover new mechanisms by which Plasminogen regulates macrophage functions. This work will significantly enhance our understanding our macrophage functions in immunity and disease.


Principal supervisor

Hong Ping Ruby Law

Additional supervisor 1

James C. Whisstock

Additional supervisor 2

Tom Caradoc-Davies

Year of Award


Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Biochemistry and Molecular Biology

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences