Characterising Plasminogen and Receptor Interactions in Macrophage Function

Macrophages are crucial cells of the immune system, being vital players in the response against infection and injury. Macrophages rely on the protein Plasminogen and its receptors (known as Plasminogen Receptors) for a variety of important functions. In this thesis, we sought to understand the specific ways that Plasminogen mediates macrophage functions. We have investigated and gained new insights into the molecular interaction between Plasminogen and its receptors. Beyond these receptors, we have also begun to uncover new mechanisms by which Plasminogen regulates macrophage functions. This work will significantly enhance our understanding our macrophage functions in immunity and disease.