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Characterisation of novel Acinetobacter baumannii type VI secretion system effectors and delivery mechanisms

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thesis
posted on 21.04.2020, 10:30 authored by JESSICA MAREE LEWIS
The prevalence of multidrug-resistant bacterial infections is on the rise globally; by 2050 multidrug resistant bacterial infections are expected to kill more than 10 million people globally, overtaking cancer and other leading illnesses. To combat this, we looked at how Acinetobacter baumannii, a notorious drug-resistant bacterial pathogen, uses antibacterial effector proteins delivered by the type VI secretion system to kill competitor bacteria in a shared environment. This work increased our knowledge of the arsenal of weapons that A. baumannii uses to kill other hospital-dwelling bacteria, which has the potential to lead to the development of novel antimicrobial strategies.

History

Principal supervisor

John Dallas Boyce

Additional supervisor 1

Marina Harper

Additional supervisor 2

Deanna Deveson Lucas

Year of Award

2020

Department, School or Centre

Microbiology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences