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Characterisation of novel Acinetobacter baumannii type VI secretion system effectors and delivery mechanisms

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posted on 2020-04-21, 10:30 authored by JESSICA MAREE LEWIS
The prevalence of multidrug-resistant bacterial infections is on the rise globally; by 2050 multidrug resistant bacterial infections are expected to kill more than 10 million people globally, overtaking cancer and other leading illnesses. To combat this, we looked at how Acinetobacter baumannii, a notorious drug-resistant bacterial pathogen, uses antibacterial effector proteins delivered by the type VI secretion system to kill competitor bacteria in a shared environment. This work increased our knowledge of the arsenal of weapons that A. baumannii uses to kill other hospital-dwelling bacteria, which has the potential to lead to the development of novel antimicrobial strategies.

History

Principal supervisor

John Dallas Boyce

Additional supervisor 1

Marina Harper

Additional supervisor 2

Deanna Deveson Lucas

Year of Award

2020

Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Microbiology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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