Monash University

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Reason: Under embargo until March 2023. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library, or by emailing

Characterisation of a novel Clostridioides difficile toxin

posted on 2022-03-24, 07:12 authored by DIANA LOPEZ-URENA
Clostridioides difficile is a bacterium that causes diarrhoea in humans and animals through toxic components. This work is part of the description of the first new toxic factor identified in the field in over 30 years, which comprises a genetic characterisation of the novel toxin. Furthermore, by using mouse models of infection, we have discovered that this toxin affects pathways that might favour the persistence of the bacterium in the gut. Altogether, we have provided new insight into the avenues by which C. difficile can interact with its host, offering a platform for future studies to explore this novel factor.


Principal supervisor

Dena Lyras

Additional supervisor 1

Steven Mileto

Additional supervisor 2

Melanie Hutton

Year of Award


Department, School or Centre


Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses