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Characterisation and validation of novel biomarkers and therapeutic candidates in paediatric inflammatory bowel disease

thesis
posted on 12.09.2022, 03:41 authored by Gemma DAdamo
Inflammatory bowel disease (IBD) is a chronic and currently incurable condition. Abnormal immune responses to the resident gut microbiome can drive or exacerbate IBD, however, these relationships are yet to be fully elucidated. Until recently, microbiome-based studies in IBD have predominantly been restricted to culture-independent sequencing-based analyses, typically of faecal samples. This reliance on both faecal samples and sequencing alone has limited understanding of host-microbiome interactions at the intestinal site of disease. This thesis defines key IBD-associated functional bacterial clades from within the patient microbiome, by combining shotgun metagenomic sequencing, bacterial culturing and host transcriptomic analysis with detailed experimental validation.

History

Principal supervisor

Sam Forster

Additional supervisor 1

Edward Giles

Additional supervisor 2

Paul Hertzog

Year of Award

2022

Department, School or Centre

Molecular and Translational Sciences

Additional Institution or Organisation

Hudson Institute for Medical Research

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences