File(s) under permanent embargo

Reason: Restricted by author. A copy can be supplied under Section 51 (2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library or by emailing document.delivery@monash.edu

Characterisation and innate immune effects of bacterial outer membrane vesicles

thesis
posted on 16.10.2017, 00:05 by NATALIE JANE BITTO
Bacteria produce tiny "grenades" known as outer membrane vesicles, or OMVs. OMVs are transported into human cells where they can manipulate the immune system to the bacteria's advantage. The first part of this study showed that OMVs carry bacterial DNA that is transported into human cells and is detectable in the nucleus. The second part of this study showed that OMVs from the bacteria Pseudomonas, a common antibiotic-resistant hospital-acquired infection, trigger a potent inflammatory response that may be involved in septic shock. Together, these findings give insight into the role of outer membrane vesicles in bacterial communication and disease progression.

History

Principal supervisor

Richard Ferrero

Additional supervisor 1

Associate Professor Katryn Stacey

Year of Award

2017

Department, School or Centre

Molecular and Translational Sciences

Additional Institution or Organisation

Hudson Institute of Medical Research

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

Exports

Exports