File(s) under permanent embargo
Reason: Under embargo until April 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library, or by emailing email@example.com
Characterisation and engineering of the streptococcal C1 phage lysin, PlyC
thesisposted on 05.04.2019, 13:31 authored by SEBASTIAN SVEN BROENDUM
Resistance to current antibiotics is reaching crisis levels and there is an urgent need to develop antibacterial agents with new modes of action. Bacteriophage infect bacteria and can cause bacterial cell death by destroying the bacterial cell wall. The bacteriophage endolysin enzymes are the agents that are responsible for this digestion of the cell wall. This function makes them an attractive alternative to traditional antibiotics. The streptococcal C1 phage lysin, PlyC, is the most potent endolysin described to date. This thesis characterises the PlyC enzyme and discovers how the unique structure of PlyC leads to its extraordinary potency and specificity.