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Cardiovascular response to birth asphyxia
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posted on 18.05.2017by Tracey Ong
Birth asphyxia is a
leading cause of neonatal mortality. Asphyxiated newborns often struggle to
make the transition from fetal to neonatal life and often require resuscitative
intervention at birth to help them successfully achieve pulmonary gas exchange
and transition the circulation from the fetal to newborn phenotype. The timing
and type of resuscitation provided to asphyxiated newborns, as outlined in
current resuscitation guidelines, heavily rely on our understanding of the
cardiorespiratory response that occurs during birth asphyxia. The studies
contained in this thesis improve our understanding of the cardiovascular
response to birth asphyxia in the ex-utero environment, in a model appropriate
for the post-natal newborn.