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Reason: Under embargo until July 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

CD8+ T cells and Cytomegalovirus in ANCA vasculitis

thesis
posted on 12.07.2021, 21:05 authored by JULI JAW
Autoimmune vasculitis commonly and critically affects the kidney. This thesis finds that inactive cytomegalovirus (CMV) infection worsen the disease in experimental animal model. Additionally, in normal kidneys CMV infection also causes more kidney changes with ageing over time. This thesis also examines a potential new therapy that targets specialised immune cells, called memory cells. It dampens systemic autoimmunity, decrease inflammation in the kidney and may potentially reduce disease severity.

History

Principal supervisor

Arthur Richard Kitching

Additional supervisor 1

Maliha Alikhan

Additional supervisor 2

Joshua Ooi

Year of Award

2021

Department, School or Centre

Medicine - Monash Health

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences