PhD Final Thesis_Nabilah.pdf (10 MB)
Breast Cancer-Targeted Delivery of Tumor Suppressor Genes, Oncogene-Specific siRNAs, and Anti-Cancer Drug Using Inorganic Nanoparticles
thesisposted on 2019-06-02, 22:24 authored by NABILAH IBNAT BABY
The performance of carbonate apatite nanoparticles (CA NPs) -mediated gene or drug delivery in terms of design and efficacy to treat breast cancer with limited side effects, has been evaluated in this research. In particular, this study had explored the effects of individual and combined delivery of a) tumor suppressor genes, such as p53, p21, BRCA1, BRCA2, PTEN and apoptotic genes related to caspase pathway like, caspase 2, caspase 3, caspase 7 and caspase 8; b) siRNAs-targeting oncogenes, i.e. PRKCA, NF-κB1 and c) traditional anti-cancer drug, vinblastine using biodegradable inorganic CA NPs, on reduction of cellular growth in breast cancer cells both in vitro and in vivo.