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PhD Final Thesis_Nabilah.pdf (10 MB)

Breast Cancer-Targeted Delivery of Tumor Suppressor Genes, Oncogene-Specific siRNAs, and Anti-Cancer Drug Using Inorganic Nanoparticles

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thesis
posted on 2019-06-02, 22:24 authored by NABILAH IBNAT BABY
The performance of carbonate apatite nanoparticles (CA NPs) -mediated gene or drug delivery in terms of design and efficacy to treat breast cancer with limited side effects, has been evaluated in this research. In particular, this study had explored the effects of individual and combined delivery of a) tumor suppressor genes, such as p53, p21, BRCA1, BRCA2, PTEN and apoptotic genes related to caspase pathway like, caspase 2, caspase 3, caspase 7 and caspase 8; b) siRNAs-targeting oncogenes, i.e. PRKCA, NF-κB1 and c) traditional anti-cancer drug, vinblastine using biodegradable inorganic CA NPs, on reduction of cellular growth in breast cancer cells both in vitro and in vivo.

History

Principal supervisor

Ezharul Hoque Chowdhury

Additional supervisor 1

Dr. Anuar Zaini

Additional supervisor 2

Dr. Nafees Ahemad

Additional supervisor 3

N/A

Additional supervisor 4

N/A

Year of Award

2019

Department, School or Centre

Jeffrey Cheah School of Medicine and Health Sciences (Monash University Malaysia)

Additional Institution or Organisation

none

Campus location

Malaysia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses

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