Monash University

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Reason: Under embargo until May 2020. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Brain Compensation in Premanifest Huntington's Disease

posted on 2019-05-22, 08:04 authored by MARIA SOLOVEVA
During premanifest stages of Huntington’s disease (pre-HD), individuals typically increase functional brain activity to compensate for widespread brain anomalies. It is somewhat problematic to unfold whether increased functional brain activity reflects a genuine compensatory response in pre-HD, or is a result of HD-related pathology. We used a quantitative model of brain compensation, known as the CRUNCH (Compensation-Related Utilization of Neural Circuits Hypothesis) to characterise compensatory processes in proactive and reactive control in pre-HD. For this purpose, we acquired structural and functional MRI (fMRI) data (n=15 pre-HD; n=15 controls) during visuospatial working and stop-signal paradigms.


Principal supervisor

Nellie Georgiou-karistianis

Additional supervisor 1

Sharna Jamadar

Year of Award


Department, School or Centre

Psychological Sciences

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences