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Biosystematics of novel Streptomyces from mangrove in Malaysia

thesis
posted on 10.04.2018, 02:36 by HOOI LENG SER
Members of family Actinobacteria, especially the genus Streptomyces have demonstrated exemplary performance in synthesizing bioactive compounds. By investigating various properties of the bacteria, the current study has identified four novel Streptomyces species from the poorly explored mangrove sediment in the east coast of Peninsular Malaysia. Among the four strains, extract of MUSC 136T showed highest toxicity towards colon cancer cells, probably triggering cell death via altering components of important pathways like p53 protein and intracellular glutathione levels. Altogether, these findings suggested that the exploration of new streptomycetes from underexplored area is a good strategy to discover useful bioactive compounds.

History

Principal supervisor

Lee Learn Han

Additional supervisor 1

Goh Bey Hing

Additional supervisor 2

Uma Devi Palanisamy

Additional supervisor 3

Chan Kok Gan

Year of Award

2018

Department, School or Centre

Jeffrey Cheah School of Medicine and Health Sciences (Monash University Malaysia)

Campus location

Malaysia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

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