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Biomaterial Characterisation of Self-Assembling β3-Peptide Hydrogels for Delivery of Therapeutics

thesis
posted on 11.10.2021, 03:54 by Meg McFetridge
Stem cell therapy holds promise to treat chronic diseases, but the short persistence of stem cells after delivery to an injured organ hampers it's therapeutic effect. New delivery methods are required to increase stem cell retention. This thesis describes the development of peptide hydrogels for long-term delivery of mesenchymal stem cells for the treatment of chronic kidney disease. New methods for hydrogel characterisation by scanning electron microscopy were developed. Novel hydrogels were developed, with cell penetrating properties which may be used in future research to deliver therapeutic cargo such as drugs.

History

Principal supervisor

Sharon Ricardo

Additional supervisor 1

Mibel Aguilar

Additional supervisor 2

Mark Del Borgo

Year of Award

2021

Department, School or Centre

Pharmacology

Additional Institution or Organisation

Biomedicine Discovery Institute

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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