Monash University
Browse

Embargoed and Restricted Access

Reason: Under embargo until 30 May 2023. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Bioengineered 3D microenvironments for in vitro T cell generation and CAR-T cell delivery

thesis
posted on 2022-08-23, 04:39 authored by ANISHA BALACHANDRAN SURAIYA
T cells are an essential arm of the adaptive immune system and are also harnessed as therapeutic agents for cancer immunotherapy. This thesis has focussed on the development of bioengineered 3-dimensional (3D) hydrogel microenvironments to address some of the unmet clinical needs related to T cells. This study demonstrates the suitability of hydrogel microstructures (microgels) as 3D culture platforms for in vitro generation of T cells with upscaling potential and for thymic epithelial cell maintenance. This research also investigates the feasibility of microgels as delivery vehicles of chimeric antigen receptor (CAR)-T cells for augmenting solid tumour immunotherapy.

History

Campus location

Australia

Principal supervisor

John Stanley Forsythe

Additional supervisor 1

Ann Chidgey

Additional supervisor 2

Nicholas Boyd

Additional supervisor 3

Richard Boyd

Year of Award

2020

Department, School or Centre

Materials Science and Engineering

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Engineering

Usage metrics

    Faculty of Engineering Theses

    Categories

    Keywords

    HydrogelsMicrogels3D co-culturesT cellsCAR-T cellsMicrofluidicsImmunotherapyCell encapsulationRegenerative Medicine (incl. Stem Cells and Tissue Engineering)Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies)Biomaterials

    Licence

    In Copyright

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC