GiannangeloCarloPhDThesis06August2018.pdf (16.54 MB)

Biochemical pathways and molecular targets involved in the mechanism of action of ozonide antimalarials in Plasmodium falciparum

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thesis
posted on 09.08.2018, 08:38 by CARLO GIANNANGELO
This thesis examined the mechanism of action of new medicines for malaria, known as ozonides. Many malaria deaths are caused by multi-drug resistant parasites that can escape the effect of current malaria medicines. This thesis identified that the parasite haemoglobin digestion pathway plays a central role in the mechanisms of action and resistance of ozonide antimalarials. This detailed mechanistic understanding will facilitate further development and clinical utilisation of ozonides by allowing rational selection of partner drugs and monitoring for resistance.

History

Campus location

Australia

Principal supervisor

Darren John Creek

Additional supervisor 1

Susan A. Charman

Year of Award

2018

Department, School or Centre

Drug Delivery, Disposition and Dynamics

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences

Exports

Exports