Bio-nano studies of organosilica and immune cells in vitro and in vivo

Nanoparticle-based nanomedicines have seen an increase in their clinical presence in the modern era, however much of the knowledge underpinning the mechanisms and interactions of these materials in biological environments is still in development. In this thesis, organosilica nanoparticles were synthesised and functionalised to investigate their bio-nano interactions with in vitro immune cell cultures as well as in a syngeneic ovarian cancer murine model