7268591_Revised Thesis_Kathy Sengmany.pdf (14.69 MB)
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Biased allosteric modulators of metabotropic glutamate receptor 5

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posted on 30.10.2018, 02:02 authored by KATHY SENGMANY
The metabotropic glutamate receptor 5 is involved in numerous central nervous system disorders. New ways of targeting this receptor for therapeutic benefits involve designing compounds which bind specific areas within the receptor such that unique receptor outcomes can be achieved. My thesis focused on characterising these compounds, what they are able to do, and how they interact with the target receptor.


Campus location


Principal supervisor

Karen Joan Gregory

Additional supervisor 1

Arthur Christopoulos

Additional supervisor 2

Stephen Alexander

Year of Award


Department, School or Centre

Drug Discovery Biology

Additional Institution or Organisation

University of Nottingham


Doctor of Philosophy (Joint Award and Doctoral Training Centre with The University of Nottingham)

Degree Type



Faculty of Pharmacy and Pharmaceutical Sciences