Biased allosteric modulators of metabotropic glutamate receptor 5
thesisposted on 30.10.2018 by KATHY SENGMANY
In order to distinguish essays and pre-prints from academic theses, we have a separate category. These are often much longer text based documents than a paper.
The metabotropic glutamate receptor 5 is involved in numerous central nervous system disorders. New ways of targeting this receptor for therapeutic benefits involve designing compounds which bind specific areas within the receptor such that unique receptor outcomes can be achieved. My thesis focused on characterising these compounds, what they are able to do, and how they interact with the target receptor.