Biased Agonism at the Adenosine Family of G Protein-Coupled Receptors

This thesis focused on investigating an important class of proteins that have been shown to play a role in a number of diseases, including heart disease, stroke and inflammation. Targeting these proteins with drugs is difficult, as severe side effects are commonly associated with treatment. In these studies, it was found that drugs without side effects could be developed. These drugs were able to do this by interacting with the proteins in a unique manner. The findings from this thesis suggest that targeting these proteins in a different way may be the key to avoiding side effects in future medicines.