Beta-adrenergic regulation of macrophage metabolism

This project investigated the effects of stress on the response of immune cells called macrophages during a pro-inflammatory stimulus. A multi-omics approach was used to evaluate the effect of beta-adrenergic stress signalling on macrophage proteins and metabolites. The findings identify an important role for stress signals in regulating central carbon metabolism, purine metabolism, and cytokine production by macrophages. These findings provide insight into how this component of the immune system protects us during health and disease.