Thesis_Laxman Kandala - Zeljka Abaza.pdf (7.66 MB)
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BF2-25-oxasmaragdyrin based systems for Near Infra-Red Fluorescence (NIRF) Imaging and Photothermal Therapy (PTT) for Cancer Treatment

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thesis
posted on 24.07.2020, 04:06 by Laxman Vamshi Krishna Kandala
Photothermal therapy has recently gained in interest for the treatment of cancer where organic agents serve as promising leads because of their biodegradable nature and low toxicity. This thesis examined expanded porphyrin macrocycles, specifically a 22π-electron BF2-oxasmaragdyrin system, which absorb and emit energy in the visible-near infra-red region. A series of materials were synthesized and evaluated for near infra-red fluorescence imaging and photothermal cancer therapy in preclinical settings. These materials could be ideal candidates for image guided theragnostic applications for clinical translation.

History

Principal supervisor

M.Ravikanth

Additional supervisor 1

Andrea Robinson

Year of Award

2020

Department, School or Centre

IITB

Degree Type

Doctorate

Faculty

Faculty of Engineering