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Application of synchrotron-based x-ray diagnostics for the investigation of pressurised metered-dose inhaler sprays

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thesis
posted on 25.11.2018 by NICHOLAS JAMES MASON-SMITH
Despite the extended and widespread use of pressurised metered-dose inhalers (pMDIs) for the treatment of respiratory disease, much remains unknown about the processes that determine their performance. Synchrotron x-ray diagnostics developed for fuel spray research are applied for the first time to pMDIs. These data confirm a long-held belief that the pMDI spray is highly vaporised at the nozzle exit. X-ray visualisations reveal internal flow phenomena that provide an explanation for the greater spray stability of pMDIs that contain cosolvent. These data are used to advance thermodynamic models that are used to predict pMDI performance.

History

Principal supervisor

Damon Robert Honnery

Additional supervisor 1

Daniel Edgington-Mitchell

Year of Award

2018

Department, School or Centre

Mechanical and Aerospace Engineering

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Engineering

Exports