Monash University
7379960_NMasonSmithPhDThesis_Revised.pdf (36.21 MB)

Application of synchrotron-based x-ray diagnostics for the investigation of pressurised metered-dose inhaler sprays

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posted on 2018-11-25, 22:24 authored by NICHOLAS JAMES MASON-SMITH
Despite the extended and widespread use of pressurised metered-dose inhalers (pMDIs) for the treatment of respiratory disease, much remains unknown about the processes that determine their performance. Synchrotron x-ray diagnostics developed for fuel spray research are applied for the first time to pMDIs. These data confirm a long-held belief that the pMDI spray is highly vaporised at the nozzle exit. X-ray visualisations reveal internal flow phenomena that provide an explanation for the greater spray stability of pMDIs that contain cosolvent. These data are used to advance thermodynamic models that are used to predict pMDI performance.


Principal supervisor

Damon Robert Honnery

Additional supervisor 1

Daniel Edgington-Mitchell

Year of Award


Department, School or Centre

Mechanical and Aerospace Engineering


Doctor of Philosophy

Degree Type



Faculty of Engineering