Antisolvent Vapour Precipitation for Particle Engineering

Antisolvent vapour precipitation process involves the exposure of the droplets containing dissolved solutes to the antisolvent vapour environment. The key step is to absorb antisolvent vapour which lowers the solutes’ solubility. This allows the dissolved solutes to precipitate and upon dehydration, leading to the production of ultrafine particles. There is currently a lack of quantitative understanding of how the absorption (and simultaneous evaporation) history of the droplets affect the precipitation behaviour of the solutes. This thesis attempted to address this gap via a combination of modelling (by developing a theoretical framework that capable for prediction study for droplet absorption-evaporation) and experimental works, based on replicating the antisolvent vapour precipitation process using the suspended single droplet drying technique.