Antimicrobial resistant urinary tract infections: Pharmacodynamic profiling of oral fosfomycin.

Sustainable and effective antibiotic therapy is a critical, lifesaving resource. Urinary tract infections are one of the most common indications for antibiotic treatment. Yet the global rise of superbugs, which are bacteria that have acquired resistance to antibiotics, now greatly limits our treatment options. Through the development of a novel and dynamic bladder infection laboratory model, this research rediscovers the optimised use of oral fosfomycin, an old antibiotic active against superbugs. By detailing efficacy under different simulations, we inform improved clinical practice to protect the activity of this antibiotic for the future.