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Anticancer activity and Molecular mechanisms of a selected diarylpentanoid treated on androgen-independent metastatic human prostate cancer cells

thesis
posted on 10.08.2017 by KAMINI CITALINGAM MUDLIAR
Prostate cancer remains incurable, highlighting a need for alternative treatment methods using natural sources. Specific structural modification on curcumin, an active ingredient of the spice turmeric to produce curcumin diarylpentanoid demonstrated improved anticancer activity on prostate cancer cells; evident by its significant growth suppressive effect and cancer killing potential. Investigation on gene and protein expression study provided an understanding into the potential anticancer activity of the compound. Overall, curcumin diarylpentanoid demonstrated potential anticancer activity and warrants further research for its use in the treatment of prostate cancer.

History

Principal supervisor

Rakesh Naidu

Additional supervisor 1

Iekhsan Othman

Additional supervisor 2

Faridah Abas

Year of Award

2017

Department, School or Centre

Jeffrey Cheah School of Medicine and Health Sciences (Monash University Malaysia)

Campus location

Malaysia

Course

Doctor of Philosophy

Degree Type

Doctorate

Faculty

Faculty of Medicine Nursing and Health Sciences

Exports