Monash University

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Anticancer activity and Molecular mechanisms of a selected diarylpentanoid treated on androgen-independent metastatic human prostate cancer cells

posted on 2017-08-10, 01:24 authored by KAMINI CITALINGAM MUDLIAR
Prostate cancer remains incurable, highlighting a need for alternative treatment methods using natural sources. Specific structural modification on curcumin, an active ingredient of the spice turmeric to produce curcumin diarylpentanoid demonstrated improved anticancer activity on prostate cancer cells; evident by its significant growth suppressive effect and cancer killing potential. Investigation on gene and protein expression study provided an understanding into the potential anticancer activity of the compound. Overall, curcumin diarylpentanoid demonstrated potential anticancer activity and warrants further research for its use in the treatment of prostate cancer.


Principal supervisor

Rakesh Naidu

Additional supervisor 1

Iekhsan Othman

Additional supervisor 2

Faridah Abas

Year of Award


Department, School or Centre

Jeffrey Cheah School of Medicine and Health Sciences (Monash University Malaysia)

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences