Monash University

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Reason: Under embargo until July 2019. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Antibiotic-associated pathogens: the use of animal models to explore disease and alternative therapeutics

posted on 2018-07-24, 07:08 authored by SARAH ALEXANDRA LARCOMBE
This thesis focused on the study of antibiotic-resistant disease-causing bacteria in the gut, exploring how they cause gut damage, and how they can be displaced without antibiotics. The prevalence of these bacteria in the gut is often impacted by antibiotic use, which creates imbalance by disrupting normal flora, and promoting antibiotic resistance. Using animal models of infection and gut colonisation, this thesis showed how a range of disease-causing bacteria can take advantage of this imbalance to cause disease, and how antibiotic resistant bacteria that cause urinary tract infections can be removed from the gut using a colostrum-based therapy.


Principal supervisor

Dena Lyras

Additional supervisor 1

Melanie Hutton

Additional supervisor 2

Helen Abud

Year of Award


Department, School or Centre


Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences