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Anti-inflammatory therapies for bronchopulmonary dysplasia

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thesis
posted on 12.03.2019 by PARIS CLARICE PAPAGIANIS
Bronchopulmonary dysplasia is a potentially fatal chronic lung disease that represents the principal cause of morbidity in infants born before 28 weeks of gestation. Both antenatal inflammation and mechanical ventilation are common antecedents that contribute to this condition. This thesis studies the effects of postnatal steroids or human amnion epithelial cells to treat and prevent brochopulmonary dysplasia. Our results suggest that tapered low-dose steroids reduces lung inflammation and injury, whilst hAECs improve lung morphology and have pro-reparative potential in lung pathology.

History

Principal supervisor

Tim Moss

Additional supervisor 1

Jane Pillow

Additional supervisor 2

Graeme Polglase

Year of Award

2019

Department, School or Centre

Obstetrics and Gynaecology

Additional Institution or Organisation

The University of Western Australia

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

Exports

Exports