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Anti-cancer Mechanism of Synthetic Curcumin Analogue 1,5-Bis(4-Hydroxy-3-Methoxyphenyl)-1,4-Pentadiene-3-One (MS13) on Neuroblastoma and Glioblastoma Cells

thesis
posted on 04.11.2020, 04:49 authored by YEE QIAN LEE
Neuroblastoma and glioblastoma are primary brain and nervous system cancers in adults and children, respectively. Both of the malignancies contribute to substantial mortality annually. In this regard, curcumin extracts from turmeric with reported anti-tumour properties against various types of cancer might serve as a potential chemotherapeutic drug that targets these malignancies. However, its poor bioavailability curtails its potential utility as an anti-cancer agent. This thesis presents the potent anti-cancer effects exhibited by a diarylpentanoid, a curcumin analogue on both neuroblastoma and glioblastoma cells and further highlights the therapeutic potential of the diarylpentanoid in treating brain malignancies in the future.

History

Principal supervisor

Rakesh Naidu

Additional supervisor 1

Pathmanathan A Rajadurai

Year of Award

2020

Department, School or Centre

Jeffrey Cheah School of Medicine and Health Sciences (Monash University Malaysia)

Campus location

Malaysia

Course

Master of Biomedical Science

Degree Type

MPHIL