Monash University

Embargoed and Restricted Access

Reason: Under embargo until 18 July 2023. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library.

Anti-TNF therapy in inflammatory bowel disease: addressing barriers to long-term therapy

posted on 2023-03-17, 04:35 authored by Ashish SrinivasanAshish Srinivasan

Anti-TNF agents represent important therapeutics in Crohn’s disease and ulcerative colitis; however, there are barriers to their long-term use. First, anti-TNF agents represent a major driver of healthcare expenditure, highlighting the need to consider cost-effective alternatives such as biosimilars. Second, a subset of patients that initially respond to anti-TNF therapy subsequently lose response. Hence, this thesis describes strategies that prioritise quality use of medicines to address these barriers by promoting the uptake of biosimilar medicines to realise substantial cost savings for Australian healthcare payers, and adopting innovative ‘virtual’ models-of-care and novel anti-TNF dosing strategies to improve clinical outcomes following loss of response.


Principal supervisor

Daniel Ross Van Langenberg

Additional supervisor 1

Peter De Cruz

Year of Award


Department, School or Centre

Eastern Health Clinical School

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences