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Anti-TNF therapy in inflammatory bowel disease: addressing barriers to long-term therapy

thesis
posted on 2023-03-17, 04:35 authored by Ashish SrinivasanAshish Srinivasan

Anti-TNF agents represent important therapeutics in Crohn’s disease and ulcerative colitis; however, there are barriers to their long-term use. First, anti-TNF agents represent a major driver of healthcare expenditure, highlighting the need to consider cost-effective alternatives such as biosimilars. Second, a subset of patients that initially respond to anti-TNF therapy subsequently lose response. Hence, this thesis describes strategies that prioritise quality use of medicines to address these barriers by promoting the uptake of biosimilar medicines to realise substantial cost savings for Australian healthcare payers, and adopting innovative ‘virtual’ models-of-care and novel anti-TNF dosing strategies to improve clinical outcomes following loss of response.

History

Principal supervisor

Daniel Ross Van Langenberg

Additional supervisor 1

Peter De Cruz

Year of Award

2022

Department, School or Centre

Eastern Health Clinical School

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses

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