Analysing Proteome Changes and Interactome Network to Elucidate the Cytotoxic Pathways of Cobra Venom Cytotoxin Exposure through Systems Biology Approach

This thesis is looking at the protein changes in human skin cells and breast cancer cells when they are exposed to cobra snake venom. Cobra snake venom is very dangerous and yet there is no effective antivenom specifically for it. By studying how this venom affects the cell, it adds to the understanding of its mechanisms and future endeavours of creating better antivenoms. Cells are treated with the venom before the proteins are extracted and sent for identification and quantification through Liquid chromatography–mass spectrometry (LC–MS) and subsequent proteomic analysis.