Monash University

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Reason: Under embargo until 30 June 2026. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library.

An investigation of the engagement of cGAS-STING signaling upon DNA damage in cancer cells

posted on 2023-06-21, 05:45 authored by SUMAIAH SAEED A AL ASMARI
When cancer cells undergo DNA damage, leakage of DNA to the cytoplasm can triggers an immune response which can be both anti-and pro-tumorigenic. This response relies on a pathway called the cGAS-STING pathway. Although this pathway is known to have anti-cancer properties, it can also produce pro-inflammatory and pro-tumorigenic factors that promote cancer growth. In this PhD project, we found that inhibiting the cGAS-STING pathway can reduce the production of pro-tumorigenic factors in some cancer cells. We also discovered that inhibiting downstream modulators of NF-κB signaling, such as ERK1/2, could help limit inflammation while retaining anti-proliferative effects. Additionally, we found that inhibiting the extracellular secretion of 2'3' cGAMP could also reduce inflammation. These findings suggest new strategies for improving cancer treatment.


Principal supervisor

Michael Gantier

Additional supervisor 1

Bryan Williams

Year of Award


Department, School or Centre

Central Clinical School

Additional Institution or Organisation

Molecular and Translational Science (Hudson Institute)

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences