Embargoed and Restricted Access
Reason: Under embargo until 09 July 2027. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
An investigation of the effect of P2X7 receptor inhibition in glioblastoma and characterisation of a novel inhibitor AZ10606120
thesis
posted on 2024-07-09, 03:49 authored by MATTHEW CHARLES DRILLGlioblastoma is the most aggressive form of brain cancer. Effective and safe treatments are urgently needed. Within the cancer cells, there is over expression of a particular protein called, P2X7R. This thesis describes P2X7R function in pre-clinical models of glioblastoma. It also describes a small molecule inhibitor of P2X7R, as a way of reducing tumour growth. The work described is hoped to lead to future clinical studies and potential novel therapeutic strategies for treatment of this devastating cancer.
