An investigation of Toll-like receptor 7 and 9 signaling in prostate cancer pathogenesis

Prostate cancer is the second most frequently diagnosed cancer in men and second highest in cancer related deaths. Overall, the current treatment strategies available are predominantly effective in early stage prostate cancer. Late stage prostate cancer is far more aggressive and current therapies are ineffective. Clearly there is a need for research into alternative treatment strategies. In this thesis, we have demonstrated that the activation of the immune system using immune sensors known as ‘toll-like receptors’, halts prostate cancer growth. Therefore, this thesis provides insight into alternative treatment strategies that utilize the immune system to fight prostate cancer.