Monash University

Embargoed and Restricted Access

Reason: Under embargo until December 2019. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

An investigation into the function of cysteine-rich secretory proteins (CRISPs) in male fertility and prostate cancer

posted on 2018-12-16, 23:01 authored by JINGHUA HU
Male fertility and reproductive health are major concerns in a modern society. Male infertility and prostate cancer can seriously affect life quality and life expectancy. This thesis focused on the roles of cysteine-rich secretory proteins (CRISPs) family proteins in male fertility and prostate cancer by using Crisp1 and Crisp4 double knockout (DKO) and Hi-MYC+Crisp3-/- mouse models. In the epididymis, CRISP1 and CRISP4 function cooperatively, and autonomously, in maintaining optimal sperm functions. CRISP3 plays a pro-tumorigenic role in prostate cancer, through modulation of key factors associated with cell-cell adhesion, thus promoting the transition from carcinoma in situ to invasive carcinoma.


Campus location


Principal supervisor

Moira Kathleen

Additional supervisor 1

Luc Furic

Year of Award


Department, School or Centre

Biological Sciences


Doctor of Philosophy

Degree Type



Faculty of Science

Usage metrics

    Faculty of Science Theses