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Reason: Under embargo until December 2019. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
An investigation into the function of cysteine-rich secretory proteins (CRISPs) in male fertility and prostate cancer
thesis
posted on 2018-12-16, 23:01 authored by JINGHUA HUMale fertility and reproductive health are major concerns in a modern society. Male infertility and prostate cancer can seriously affect life quality and life expectancy. This thesis focused on the roles of cysteine-rich secretory proteins (CRISPs) family proteins in male fertility and prostate cancer by using Crisp1 and Crisp4 double knockout (DKO) and Hi-MYC+Crisp3-/- mouse models. In the epididymis, CRISP1 and CRISP4 function cooperatively, and autonomously, in maintaining optimal sperm functions. CRISP3 plays a pro-tumorigenic role in prostate cancer, through modulation of key factors associated with cell-cell adhesion, thus promoting the transition from carcinoma in situ to invasive carcinoma.
